For Our Patients
Clinical Trials and Research
All Upcoming
Studies
Clinical trials are designed to test the safety and efficacy of new apporaches to preventing, detecting, and treating disease. Research and clinical trials also continuously look for new ways to use existing treatments, new drugs, surgical procedures and devices.
Florida Retina Institute clinical trial participants may enroll to possibly receive the newest treatment for their vitreoretinal conditions, as well as to have additional care and attention from clinical trial staff and with the results and outcome of their trial, help researchers find better treatments for future patients.
Detailed information about all Upcoming Studies
For Central Florida Patients
Hornbill Study
Diabetic Retinopathy with Diabetic Macula Ischemia
Central Florida Patients
A study to test the different doses of BI 764524 in patients who have had laser treatment for a type of diabetic eye disease called Diabetic Retinopathy with Diabetic Macula Ischemia.
New Day Study
Diabetic Macula Edema
Central Florida Patients
A Randomized, masked, controlled study of and intravitreal ILUVIEN implant as baseline therapy in patients with early Diabetic Macular Edema.
Kodiak P104 (Gleam) Study
Diabetic Macula Edema
Central Florida Patients
Randomized, double masked Phase 3 study to evaluate the efficacy and safety of intravitreal KSI-301 compared with intravitreal Aflibercept in participants with visual impairment secondary to treatment-naïve patients with diabetic macular edema (GLEAM and GLIMMER) and macular edema due to retinal vein occlusion (BEACON).
Kodiak P103 (Beacon) Study
Macular Edema Secondary to Retinal Vein Occlusion
Central Florida Patients
A randomized, double masked Phase 3 study to evaluate the efficacy and safety of intravitreal KSI-301 compared with intravitreal Aflibercept in participants with visual impairment secondary to treatment-naïve Macular Edema secondary to Retinal Vein Occlusion.
Protocol PU-AD-SD-0201 – Samus Therapeutics, Inc.
Central Florida Patients
A Phase 2A study to evaluate safety, tolerability and pharmacological effect of PU-AD in subjects with mild Alzheimer’s Disease (AD) dementia. For more detailed information about this study, please click here.
Protocol GS-US-389-3933 – Gilead Sciences, Inc.
Central Florida Patients
A Phase 1 Open-Label, Parallel-Group, Adaptive, Single-Dose Study to Evaluate the Pharmacokinetics of GS-9688 in Subjects with Normal and Impaired Hepatic Function. For more detailed information about this study, please click here.
Protocol GO29665
Central Florida Patients
A Phase I/II, Multicenter, Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Patients with Previously treated Solid Tumors. This study is in conjunction with Orlando Health, Arnold Palmer Hospital for Health.
Closed for enrollment but actively seeing current patients for 4 years-duration of study. For more detailed information about this study, please click here.
For North Florida Patients
DRCR-Protocol AF
Diabetic Retinopathy
North Florida Patients
A Randomized Clinical Trial Evaluating Fenofibrate for Prevention of Diabetic Retinopathy Worsening.
This randomized trial will evaluate the effect of fenofibrate compared with placebo for prevention of diabetic retinopathy worsening through 4 years of follow-up in participants with mild to moderately severe non-proliferative diabetic retinopathy.
DRCR-Protocol AJ
Macular Hole
North Florida Patients
Vitreous Proteomics in Eyes with a Macular Hole. The main objective of this protocol is to verify and characterize abnormally expressed vitreous proteins in adults with macular hole and to identify biological pathways involved in the pathogenesis of macular hole formation and potential targets for therapeutic intervention.
DRCR Protocol GEN-Genetics in Retinal Diseases
North Florida Patients
To better understand the effects of diabetes on the retina, the Diabetic Retinopathy Clinical Research Network (DRCR.net) is collecting a blood sample from people with diabetes.
The blood sample will be used to extract DNA. DNA is the part of a cell that contains unique genetic information.
It is hoped that through studies done on the DNA, scientists will develop a better understanding of how diabetes causes changes in the retina and how diabetic retinopathy can best be treated.
Novartis Protocol RTH258D2301-PDR (CONDOR)
Proliferative Diabetic Retinopathy (PDR)
Central Florida and North Florida Patients
A 96-week, two arm, randomized, single-masked, multi-center, phase III study assessing the efficacy and safety of brolucizumab 6 mg compared to panretinal photocoagulation laser in patients with proliferative diabetic retinopathy.
The purpose of this study is to evaluate the efficacy and safety of brolucizumab compared to PRP in subjects with PDR.
Regeneron Protocol 20968 (PULSAR)
Wet Macular Degeneration
Central Florida and North Florida Patients
Randomized, Double-Masked, Active-Controlled, Phase 3 Study of Efficacy and Safety of High Dose Aflibercept in Patients With Neovascular Age-Related Macular Degeneration.
UPCOMING STUDIES
Annexon Study
Geographic Atrophy Secondary to Age-Related Macular Degeneration
Central Florida and North Florida Patients
A phase 2, randomized, double masked, 4-armed, Sham controlled study of the efficacy, safety, and tolerability of ANX007 administered by intravitreal injections in patients with Geographic Atrophy secondary to age-related macular degeneration.
Gyroscope Study
Geographic Atrophy Secondary to Age-Related Macular Degeneration
Central Florida and North Florida Patients
To evaluate subjects with for Geographic Atrophy Secondary to Age-Related Macular Degeneration by sequencing selected genes associated with AMD. Subjects who meet eligibility criteria will have the option to participate in ongoing or future Gyroscope Therapeutic sponsored studies.
If you want to see a list of clinical trials, please click here and go to Clinicaltrials.gov, a resource provided by the U.S. National Library of Medicine. ClinicalTrials.gov is a database of privately and publicly funded clinical studies conducted around the world.
