For Our Patients


Clinical Trials and Research

Clinical trials are designed to test the safety and efficacy of new apporaches to preventing, detecting, and treating disease. Research and clinical trials also continuously look for new ways to use existing treatments, new drugs, surgical procedures and devices.

Florida Retina Institute clinical trial participants may enroll to possibly receive the newest treatment for their vitreoretinal conditions, as well as to have additional care and attention from clinical trial staff and with the results and outcome of their trial, help researchers find better treatments for future patients.

Detailed information about all Upcoming Studies

For Central Florida Patients

Hornbill Study

Diabetic Retinopathy with Diabetic Macula Ischemia

Central Florida Patients

A study to test the different doses of BI 764524 in patients who have had laser treatment for a type of diabetic eye disease called Diabetic Retinopathy with Diabetic Macula Ischemia.

Enroll in this Study

New Day Study

Diabetic Macula Edema

Central Florida Patients

A Randomized, masked, controlled study of and intravitreal ILUVIEN implant as baseline therapy in patients with early Diabetic Macular Edema.

Enroll in this Study

Kodiak P104 (Gleam) Study

Diabetic Macula Edema

Central Florida Patients

Randomized, double masked Phase 3 study to evaluate the efficacy and safety of intravitreal KSI-301 compared with intravitreal Aflibercept in participants with visual impairment secondary to treatment-naïve patients with diabetic macular edema (GLEAM and GLIMMER) and macular edema due to retinal vein occlusion (BEACON).

Enroll in this Study

Kodiak P103 (Beacon) Study

Macular Edema Secondary to Retinal Vein Occlusion

Central Florida Patients

A randomized, double masked Phase 3 study to evaluate the efficacy and safety of intravitreal KSI-301 compared with intravitreal Aflibercept in participants with visual impairment secondary to treatment-naïve Macular Edema secondary to Retinal Vein Occlusion.

Enroll in this Study

Protocol PU-AD-SD-0201 – Samus Therapeutics, Inc.

Central Florida Patients

A Phase 2A study to evaluate safety, tolerability and pharmacological effect of PU-AD in subjects with mild Alzheimer’s Disease (AD) dementia. For more detailed information about this study, please click here.

Enroll in this Study

Protocol GS-US-389-3933 – Gilead Sciences, Inc.

Central Florida Patients

A Phase 1 Open-Label, Parallel-Group, Adaptive, Single-Dose Study to Evaluate the Pharmacokinetics of GS-9688 in Subjects with Normal and Impaired Hepatic Function. For more detailed information about this study, please click here.

Enroll in this Study

Protocol GO29665

Central Florida Patients

A Phase I/II, Multicenter, Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Patients with Previously treated Solid Tumors. This study is in conjunction with Orlando Health, Arnold Palmer Hospital for Health.

Closed for enrollment but actively seeing current patients for 4 years-duration of study. For more detailed information about this study, please click here.

For North Florida Patients

DRCR-Protocol AF

Diabetic Retinopathy

North Florida Patients

A Randomized Clinical Trial Evaluating Fenofibrate for Prevention of Diabetic Retinopathy Worsening.

This randomized trial will evaluate the effect of fenofibrate compared with placebo for prevention of diabetic retinopathy worsening through 4 years of follow-up in participants with mild to moderately severe non-proliferative diabetic retinopathy.

Enroll in this Study

DRCR-Protocol AJ

Macular Hole

North Florida Patients

Vitreous Proteomics in Eyes with a Macular Hole. The main objective of this protocol is to verify and characterize abnormally expressed vitreous proteins in adults with macular hole and to identify biological pathways involved in the pathogenesis of macular hole formation and potential targets for therapeutic intervention.

Enroll in this Study

DRCR Protocol GEN-Genetics in Retinal Diseases

North Florida Patients

To better understand the effects of diabetes on the retina, the Diabetic Retinopathy Clinical Research Network (DRCR.net) is collecting a blood sample from people with diabetes.

The blood sample will be used to extract DNA. DNA is the part of a cell that contains unique genetic information.

It is hoped that through studies done on the DNA, scientists will develop a better understanding of how diabetes causes changes in the retina and how diabetic retinopathy can best be treated.

Enroll in this Study

Novartis Protocol RTH258D2301-PDR (CONDOR)

Proliferative Diabetic Retinopathy (PDR)

Central Florida and North Florida Patients

A 96-week, two arm, randomized, single-masked, multi-center, phase III study assessing the efficacy and safety of brolucizumab 6 mg compared to panretinal photocoagulation laser in patients with proliferative diabetic retinopathy.

The purpose of this study is to evaluate the efficacy and safety of brolucizumab compared to PRP in subjects with PDR.

Enroll in this Study

Regeneron Protocol 20968 (PULSAR)

Wet Macular Degeneration

Central Florida and North Florida Patients

Randomized, Double-Masked, Active-Controlled, Phase 3 Study of Efficacy and Safety of High Dose Aflibercept in Patients With Neovascular Age-Related Macular Degeneration.

Enroll in this Study

UPCOMING STUDIES

Annexon Study

Geographic Atrophy Secondary to Age-Related Macular Degeneration

Central Florida and North Florida Patients

A phase 2, randomized, double masked, 4-armed, Sham controlled study of the efficacy, safety, and tolerability of ANX007 administered by intravitreal injections in patients with Geographic Atrophy secondary to age-related macular degeneration.

Enroll in this Study

Gyroscope Study

Geographic Atrophy Secondary to Age-Related Macular Degeneration

Central Florida and North Florida Patients

To evaluate subjects with for Geographic Atrophy Secondary to Age-Related Macular Degeneration by sequencing selected genes associated with AMD. Subjects who meet eligibility criteria will have the option to participate in ongoing or future Gyroscope Therapeutic sponsored studies.

Enroll in this Study

If you want to see a list of clinical trials, please click here and go to Clinicaltrials.gov, a resource provided by the U.S. National Library of Medicine. ClinicalTrials.gov is a database of privately and publicly funded clinical studies conducted around the world.